Meet our new peptide: Activated Silk™ KDF

February 4, 2025

Introducing Activated Silk™ KDF-β:
The Natural Solution For Modern Skin Stressors

  • Today’s environment has introduced new oxidative stressors to our skin, resulting in damage, hyperpigmentation, and accelerated aging.
  • Conventional skincare defenses can no longer keep up.
  • Activated Silk™ KDF-β is the only naturally derived bioactive peptide designed for the challenge, due to its ability to support the increased natural regeneration rate of skin.
  • Increased regeneration means that damaged skin cells are cycled out faster and more frequently, resulting in rapid improvement in the appearance of damaged skin and redness, while improving skin barrier integrity.

Evolved By Nature is proud to announce the launch of its newest bioactive peptide, Activated Silk™ KDF-β, a first-of-its-kind natural keratinocyte differentiation factor peptide. This advanced skincare ingredient supports natural processes to promote the formation of a hydrated epidermal layer, rapidly counteracting modern levels of UV exposure and oxidative stress. It is the fourth peptide to be launched on Evolved By Nature’s naturally derived and science-backed Activated Silk™ platform for skincare.

Update Your Skin Defense To Fight Modern Aggressors

Environmental factors like damaging UV rays, climate change, and increased pollution have  dramatically increased the number of free radicals that cause oxidative stress damage on the skin. Year after year, it’s only getting worse; UV levels have increased in certain places by up to 6% over a 30 year period, along with UV-driven cancers. A new kind of ingredient is needed, not just to bring immediate, visible improvement to the skin, but to also help the skin rejuvenate by moving out damaged cells which could cause long term impacts if not cycled through in an optimized manner. 

While legacy skincare ingredients like hyaluronic acid, retinol, and Vitamin C happen to address some symptoms of oxidative stress, they were not designed specifically for the problem. 

Activated Silk™ KDF-β is a breakthrough ingredient, purposely developed to help skin adapt to today’s evolving environmental challenges. This innovative ingredient is specifically designed to support natural regeneration and protect the skin from oxidative stress damage, which can cause a range of issues such as dullness, uneven complexion, hyperpigmentation, discoloration, accelerated signs of aging, inflammation, and atopic skin issues. Offering a proactive and preventative approach to modern skincare, Activated Silk™ KDF-β helps to cycle out the signs of older or damaged skin cells and supports a more robust and protective skin barrier.

Repair and Renew: Promoting Natural Skin Regeneration

Quick science lesson: The epidermis is the outermost layer of the skin and consists of five distinct layers — the stratum corneum, stratum lucideum, stratum granulosum, stratum spinosum, and stratum basale. The deepest layer of the epidermis — the stratum basale — is where new skin cells, like keratinocytes, are generated. These keratinocytes play a crucial role in the skin’s defense against external elements. Activated Silk™ KDF-β, supports keratinocytes in their journey upward to the stratum corneum, where they push out older, damaged cells and form a renewed barrier.

Activated Silk™ KDF-β also supports the natural upregulation and production of beneficial skin health proteins: involucrin for elasticity, filaggrin for hydration, and claudin for skin barrier integrity. Delivering these supportive proteins further helps to strengthen the skin barrier and protect against oxidative stress.

Unlike legacy ingredients, Activated Silk™ KDF-β was developed with the philosophy that an ingredient meant to promote youthful, healthy looking skin should not cause irritation or risk harm. As a result, it is proven safe for even the most sensitive skin, suitable for daily use and sun exposure, and can be easily incorporated into any formulation. Furthermore, in a head-to-head clinical study, Activated Silk™ KDF-β displayed remarkable reduction in the appearance of damaged skin, in the appearance of symptoms associated with eczema prone skin, and in the reduction of the appearance of redness.

Activated Silk™ KDF-β is also a natural ingredient, designed with the principles of biotechnology. It is made with upcycled ingredients, cruelty-free sourcing, and renewable energy. Unlike synthetic peptides which commonly use deleterious processing chemicals that produce harmful effluents, Activated Silk KDF-β uses only silk protein, water and concentrated salts. It also supports eight of the 17 United Nations Sustainable Development Goals, contributes to a circular economy, and has vastly increased levels of sustainability compared to outdated ingredients.

Brian Freedman, Regional Director of North America, Natural Ingredients at Evolved By Nature: “Traditional skincare ingredients like hyaluronic acid, retinol, and Vitamin C were developed decades ago, making them an outdated defense to modern aggressors. Adverse environmental conditions have increased over the past decades and reliable skincare hasn’t kept pace. That’s why we’re thrilled to offer a new solution to skincare innovators. Activated Silk™ KDF-β is the only ingredient designed for this modern challenge. It’s an innovative solution that delivers real, targeted protection and renewal for today’s skincare challenges.”

Activated Silk™ KDF-β is now market-ready and available for incorporation into skincare formulations. Please contact [email protected] to get started and try a free sample.

And learn more about Evolved By Nature’s latest innovations at https://bioactives.evolvedbynature.com/

About Evolved By Nature

Evolved By Nature is a life sciences company, and a pioneer in natural peptide discovery using a novel biotechnology process to isolate and manipulate peptides derived from natural, renewable resources to create barrier-enhancing products. These products include a range of bioactives, therapeutics and ingredients that increase performance while helping industries from personal care to fashion replace harmful chemicals and synthetics, ending their reliance on CO₂ prolific supply chains and production processes.

www.evolvedbynature.com