Activated Silk™ 33B Bioactive Peptide Solution

Better skin barrier.
Better biotechnology.
Better future.

INCI: Soluble Fibroin

  • Clinically Proven
  • Sustainable†
  • Upcycled
  • Biodegradable
  • Natural

†The manufacturing of Activated Silk™ biotechnology is environmentally responsible and developed with good work practices, which contributes to achieving U.N. Sustainable Development Goals. For more information, visit sdgs.un.org/goals

Activated Silk™ 33B Bioactive Peptide Solution

Activated Silk™ 33B is a bioactive peptide solution that boosts the skin barrier. An improved barrier locks in moisture and locks out instigators that can lead to inflammation. So skin looks and feels healthier.

INCI: Soluble Fibroin

Activated Silk™ 33B:

  • an anti-aging ingredient that firms and hydrates the skin to reduce the appearance of fine lines and wrinkles.
  • a non-occlusive ingredient that boosts the skin’s ability to maintain its own barrier against instigators that could lead to inflammation.
  • a water-soluble peptide that works in places ceramides and petrolatum cannot.

Activated Silk™ 33B Bioactive Peptide Solution

Activated Silk™ 33B also contributes to a healthier planet by being sustainable†, upcycled, all-natural, biodegradable, biobased and cruelty free.

INCI: Soluble Fibroin

Made by nature.
Evolved by biotechnology.

  1. Mulberry plants are grown organically on 6 of 7 continents, fix soil, prevent erosion, and require only rainwater.
  2. Mulberry farms provide decent work, economic growth and inclusive employment.
  3. Only a portion of the plant’s pesticide-free mulberry leaves are needed to feed silkworms.
  4. In a cruelty-free process, silkworms are reared on mulberry, and their waste is used to fertilize the environment.
  5. Silkworms spin cocoons of natural silk fiber and de-differentiate into pupae.
  6. Silkworm pupae become a vital food source for various animals, inluding chicken and fish.
  7. Cocoons are upcycled for biotech development rather than discarded as industrial waste.
  8. We use renewable energy and are an equitable employment company that does not create waste.

†The manufacturing of Activated Silk™ biotechnology is environmentally responsible and developed with good work practices, which contributes to achieving U.N. Sustainable Development Goals. For more information, visit sdgs.un.org/goals

Better Skin Barrier.

The tiny gaps between your skin cells are called junctions. To improve your skin barrier you need those junctions to be tight. This will prevent environmental stressors from entering the skin and hydration from escaping, which can result in less appearance of redness, irritation and signs of aging. Our skin cells produce a little-known protein called Claudin that helps keep your junctions tight. And now theres a polypeptide solution that supports the skin’s natural production of Claudin. Keep scrolling.

INCI: Soluble Fibroin

Fig. 1 - Without Claudin
Fig. 2 - With Claudin

Better Biotechnology.

Activated Silk™ 33B supports the skin’s natural production of Claudin. This natural protein binds skin cells together, which keeps moisture in and irritants out, resulting in a skin barrier that looks and feels healthier. Speaking of results, Activated Silk™ 33B has been clinically proven to calm the appearance of redness, irritation, and promote firmer younger looking skin.

INCI: Soluble Fibroin

  • Activated Silk™
  • Claudin-1
  • Activated Silk™ 33B
  • Cell Body
  • DNA
Fig. 1 - Non-occlusive Activated Silk™ 33B Fig. 2 - Activated Silk™ 33B supports the skin’s natural production of Claudin. Fig. 3 - Claudin-1 binds skin cells together.
  1. Non-occlusive Activated Silk™ 33B Fig.1
  2. Activated Silk™ 33B supports the skin’s natural production of Claudin. Fig.2
  3. Claudin-1 binds skin cells together. Fig.3

Better Results.

These are the results from a study we performed to evaluate the skin barrier before and after the application of Activated Silk™ 33B.

INCI: Soluble Fibroin

Barrier Enhancement
Ex-Vivo Human Skin Study

Claudin-1 Cell Nuclei

&bsp;

Fig 1. No Activated Silk™ 33B

Fig 2. Activated Silk™ 2% 33B

Better Results.

These are the results from a study we performed to evaluate the skin barrier before and after the application of Activated Silk™ 33B.

INCI: Soluble Fibroin

Activated Silk™ 33B vs
Placebo Control

  1. TEWL
  2. Redness
  3. Wrinkles

We actually conducted a head-to-head study versus a placebo control.

Results

  • Reduction in TEWL (Transepidermal Water Loss)
  • Reduction in appearance of redness
  • Reduction in appearance of fine lines

Study Design:
The study was a monadic single-blind, single center, home use design. Thirty-four subjects participated in a 28-day treatment period. Thirty-four female subjects were issued the test article to use on the face twice a day, morning and evening, over the 28-day study duration.

Better Results.

These are the results from a study we performed to evaluate the skin barrier before and after the application of Activated Silk™ 33B.

INCI: Soluble Fibroin

Activated Silk™ 33B vs
Placebo Control Expert Graded

Results Significant reduction in TEWL (transepidermal water loss) by 18%

  1. TEWL
  2. Redness
  3. Wrinkles

Better Results.

These are the results from a study we performed to evaluate the skin barrier before and after the application of Activated Silk™ 33B.

INCI: Soluble Fibroin

Activated Silk™ 33B vs
Placebo Control Expert Graded

Results Appearance of redness was significantly reduced in as little as 7 Days

  1. TEWL
  2. Redness
  3. Wrinkles

Better Results.

These are the results from a study we performed to evaluate the skin barrier before and after the application of Activated Silk™ 33B.

INCI: Soluble Fibroin

Activated Silk™ 33B vs
Placebo Control Expert Graded

Results Reduction in appearance of fine lines & wrinkles.

  1. TEWL
  2. Redness
  3. Wrinkles

Better For The Planet.

Not only does Activated Silk™ 33B make your skin look and feel healthier, it also makes the planet healthier. Unlike the fossil fuel-derived petrochemicals often used in skin care products, Activated Silk™ 33B is sustainable, all-natural, biodegradable, made from renewable energy and supports a circular economy in a better way. Our only byproducts are salt and water.

INCI: Soluble Fibroin

Sustainability Claims

  • Sustainable
  • 100% Biodegradable
  • Cruelty-Free (Leaping Bunny Certified)
  • Petrochemical Free
  • Non-Toxic
  • Made From a Renewable Resource
  • Supportive of a Circular Economy
  • Made With Renewable Energy
  • Upcycled
  • Shipping Efficiencies
    Reduce Carbon Footprint

Better Carbon Footprint.

Activated Silk™ 33B biotechnology is delivered in a lyophilized tablet form. Why? Because it makes it easier to ship, store and use than petrolatum, which only comes in 55 gallon drums. This means it’s better for your business/ budget and carbon footprint.

INCI: Soluble Fibroin

When compared to standard liquid, waxy or petrolatum ingredients, Activated Silk™:

  • Reduces the shipping burden by 90.5%*
  • Reduces plastic packaging by 56%*
  • Is renewably sourced, upcycled and 100% Biodegradable
  • Is compact for easy storage Compact

Let’s Make Better Things Together.

INCI: Soluble Fibroin

Data Substantiations (available upon request)

  • 200 Person HRIPT
  • Cytotoxicity in EpiDermFT in Vitro Skin Model
  • 28 Day Clinical Study - Expert Grading
  • 28 Day Clinical Study - Corneometer Measurements
  • 28 Day Clinical Study - Tewameter Measurements