Activated Silk™ 27P-α Bioactive Peptide

Pro-collagen
pro-health
peptide solution.

INCI: 0.25% to 0.5% Range

  • Supports natural production of collagen
  • 100% Natural (NATRUE APPROVED†)
  • Sustainable††
  • Upcycled
  • Suitable for sensitive skin/sun

† Activated Silk™ peptides are naturally-derived. For more information on NATRUE approvals, see www.natrue.org
†† The manufacturing of Activated Silk™ biotechnology is environmentally responsible and developed with good work practices, which contributes to achieving U.N. Sustainable Development Goals. For more information, visit sdgs.un.org/goals

Activated Silk™ 27P-α Bioactive Peptide

A Good Solution Every Step of the Way

We have spent 10 years innovating Activated Silk™ biotechnology on a mission to advance the health of people and the planet.

Upcycled. Renewable.
Cruelty-free. Sustainable.†

  1. Mulberry plants are grown on 6 of 7 continents, supporting good soil, fixing erosion, and sequestering carbon.
  2. Mulberry farms provide decent work, economic growth and inclusive employment.
  3. Only a portion of the plant’s mulberry leaves are needed to feed silkworms.
  4. Silkworms spin cocoons of natural silk fiber and de-differentiate into pupae.
  5. Silkworm pupae become a vital food source for various animals, icnluding chicken and fish.
  6. Cocoons are upcycled for biotech development rather than discarded as industrial waste.
  7. Evolved By Nature uses renewable energy and is an equitable employment company.

†The manufacturing of Activated Silk™ biotechnology is environmentally responsible and developed with good work practices, which contributes to achieving U.N. Sustainable Development Goals. For more information, visit sdgs.un.org/goals

Activated Silk™ 27P-α Bioactive Peptide

Everybody Knows Collagen

Collagen is a scaffolding protein produced in skin cells to give our skin its firmness and elasticity. These are the elements that give us the appearance of youthful, energetic skin. Due to internal and external factors, we all experience less collagen production over time — leading to wrinkles and fine lines.

But did you know maintaining that youthful appearance is actually a two‑part system?

Collagen Production

Collagen production occurs mainly in the cells called fibroblasts. These fibroblasts produce many types of collagen, Type 1 being the most abundant — approximately 90% of the collagen in the dermis is Type 1. The more Type 1 collagen you produce, the healthier and stronger your skin matrix will be.

Collagen Stabilization

As we age, there is a natural upregulation of enzymes called collagenases. These enzymes degrade collagen fibers, resulting in collagen fragmentation that compromises the structural integrity of the skin matrix. Reducing the production of collagenase can help to maintain a strong, healthy skin matrix.

Activated Silk™ 27P-α Bioactive Peptide

Reactivate Your Natural Collagen Production

Retinol, widely regarded as the gold standard of anti-aging components, doesn’t actually construct the collagen Matrix, it’s primarily focused on stopping the degradation of existing collagen.

As pioneers in peptide chemistry, we engineered a novel ingredient that supports the natural production of foundational collagen, as seen in step 1.

Two steps required for maintaining collagen

Step 1:

Skin cells secrete Pro‑collagen.

~90% pro-collagen
Type 1 forms the collagen matrix.

Step 2:

Collagen Stabilization

Preventing collagenase enzymes from breaking down the collagen matrix.

Activated Silk™ 27P-α Bioactive Peptide

A Naturally Derived Peptide with Supernatural Abilities

Activated Silk™ 27P-α is a collagen-supporting bioactive peptide solution that is gentle enough for sensitive skin and everyday use.

  • No known side effects commonly associated with collagen ingredients, like skin irritation, sensitivity or product stability issues.
  • Suitable for sensitive skin and use in the sun.
  • Easy to formulate with.
  • Supports natural production of Type 1 collagen, the most prominent and valuable form of collagen in the dermis.
  • Combinatorial effects with other collagen ingredients.
  • Elevates skin plumpness and elasticity, leading to reduced appearance of fine lines, wrinkles and redness.

Activated Silk™ 27P-α Bioactive Peptide

A Bioactive Team Player

Activated Silk™ 27P-α bioactive peptide solution could supercharge your existing formulas.

27P-α

Activated Silk™ 27P-α is a sole pro‑collagen ingredient, and it will not only reduce the appearance of fine lines, wrinkles, redness and irritation, but also allow the skin to be more receptive to retinol and vitamin C products.

27P-α + Retinols

Formulate Activated Silk™ 27P-α with retinols to stabilize the mature matrix for longer lasting collagen.

27P-α + Vitamin C

Formulate Activated Silk™ 27P-α with Vitamin C to help convert pro‑collagen into a mature collagen matrix for more effective collagenesis.

Activated Silk™ 27P-α Bioactive Peptide

The New Pro-Collagen Gold Standard

It is scientifically proven to significantly support natural production of Type 1 collagen levels. And we tested it against TGF-β, a growth factor used by laboratories needing to quickly generate significant amounts of collagen for medical research. TGF-β sells for $50,000/kg.

In Vitro Sample Data

Conclusions

Activated Silk™ 27P-α significantly supports natural production of Type 1 collagen.

Fold change in Pro-Collagen Secretion
Fold change in deposited collagen

Sources: *At .5% concentration

Activated Silk™ 27P-α Bioactive Peptide

The New Pro-Collagen Gold Standard

No commercial ingredient exists that produces Type 1 collagen. And we tested it against the laboratory ingredient TGF-β, an exclusive accelerant used by scientists to generate collagen for medical research.

Microscopic View

Conclusions

Activated Silk™ 27P-α significantly supports natural production of Type 1 collagen.

Baseline**

Activated Silk™ 27P-α**

**Magnification level 10X.

Activated Silk™ 27P-α Bioactive Peptide

Noticeably Younger, Healthier Looking Skin

Activated Silk™ 27P is currently in the pre-launch phase, and will be commercially launched when full and robust sets of 28 day clinical data have been generated.

Initial results are exceptional.

.5% Activated Silk™ 27P vs Placebo

= area of noticeble improvement

Phase 1 Clinical Trials
Complete first week of March 2024

Phase 2 Clinical Trials
Complete in April 2024

1 / 4

Day 0

Day 14

Source: Interim Check-in on EBN 27P Consumer Perception Results 28 day study. Day 0-14, n=20, January 16-30, 2024: individual results may vary.

Activated Silk™ 27P-α Bioactive Peptide

Pro-Collagen. Pro-Health. Pro‑Nature.

Not only does Activated Silk™ 27P-α bioactive peptide make your skin look and feel healthier, it also makes the planet healthier. Unlike the fossil fuel-derived petrochemicals often used in skincare products, Activated Silk™ 27P-α is a 100% natural ingredient to create more sustainable products and help you hit your sustainability and natural ingredient marks.

Sustainability Claims

  • 100% Natural (NATRUE Approved†)
  • Biodegradable
  • Cruelty-Free (Leaping Bunny Certified)
  • Not formulated with Petrochemicals
  • Nontoxic††
  • Made From a Renewable Resource
  • Supportive of a Circular Economy
  • Made With Renewable Energy
  • Reduces Packaging / Shipping Footprint
  • Upcycled

† Activated Silk™ peptides are naturally-derived. For more information on NATRUE approvals, see www.natrue.org
†† Based on completion of HRIPT, heavy metal testing, ASTM D5338 biodegradability and aquatic toxicity testing.

Activated Silk™ 27P-α Bioactive Peptide

Shipping with a Softer Footprint.

Activated Silk™ 27P-α bioactive peptide solution is shipped in lyophilized tablet form. You then combine the tablets with RODI water to make a 10% (w/v) solution.

When compared to a standard liquid, waxy or petrolatum ingredients, Activated Silk™ 27P-α:

  • Reduces the shipping burden by 90.5%*
  • Reduces plastic packaging by 56%*
  • Renewably sourced, upcycled and 100% biodegradable in water, making it supportive of a circular economy.
  • Is compact for easy storage Compact

*Compared to standard 55-gallon drum liquid ingredient

Activated Silk™ 27P-α Bioactive Peptide

Let’s formulate a healthier
future together.

Data Substantiations (available upon request)

  • 14 Day Clinical Study
  • Expert Grading
  • 28 Day Clinical Study Results Pending